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Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

✍ Scribed by P. C. WONG; E. J. CRAIN; B. XIN; R. R. WEXLER; P. Y. S. LAM; D. J. PINTO; J. M. LUETTGEN; R. M. KNABB


Book ID
109152497
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
371 KB
Volume
6
Category
Article
ISSN
1538-7933

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## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth