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Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells

✍ Scribed by Mee-Young Ahn; Sang-Gun Ahn; Jung-Hoon Yoon


Book ID
113834079
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
992 KB
Volume
47
Category
Article
ISSN
1368-8375

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec