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Apical barriers to airway epithelial cell gene transfer with amphotropic retroviral vectors

โœ Scribed by Wang, G; Williams, G; Xia, H; Hickey, M; Shao, J; Davidson, B L; McCray, P B


Book ID
110039068
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
607 KB
Volume
9
Category
Article
ISSN
0969-7128

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## Abstract Lentivirus vectors are being investigated as gene delivery vehicles for cystic fibrosis airway gene therapy. Vesicular stomatitis virus G glycoprotein (VSVโ€G)โ€pseudotyped vectors transduce airway epithelia via receptors that are located predominantly on the basolateral surface of the ai