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Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

✍ Scribed by IKEGAMI, SUSUMU; TAGUCHI, TAKAHIKO; OHASHI, MOCHIHIKO; OGURO, MIEKO; NAGANO, HIROSHI; MANO, YOSHITAKE


Book ID
109710885
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
322 KB
Volume
275
Category
Article
ISSN
0028-0836

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We have investigated whether or not ATP or other nucleoside di-and trisphosphates (including some nonhydrolysable ATP analogues) can stimulate the activity and/or the processivity of DNA polymerase a: associated with the nuclear matrix obtained from HeLa S3 cell nuclei that had been stabilized at 37