✦ LIBER ✦

APDR5 -independent pathway of multi-drug resistance regulated by theSIN4 gene product

✍ Scribed by Fleckenstein, Anne; Shallom, Joshua; Golin, John

Book ID: 101226529
Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 146 KB
Volume: 15
Category: Article
ISSN: 0749-503X
DOI: 10.1002/(sici)1097-0061(19990130)15:2<133::aid-yea354>3.0.co;2-v

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✦ Synopsis

The SIN4 locus encodes a global transcriptional regulator of various yeast genes. In this report, we demonstrate that loss of function mutations in SIN4 create a multi-drug hypersensitive phenotype that is independent of PDR5 mediated resistance. Thus, double sin4, pdr5 mutants are more sensitive than single mutants. Furthermore, SIN4 does not regulate the PDR5 locus. These observations establish that yeast cells have two genetically distinct pathways conferring resistance towards similar substrates.

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