Apatite as carrier for growth hormone:In vitro characterization of loading and release

✍ Scribed by Guicheux, J�r�me ;Grimandi, Gael ;Tr�cant, Maryl�ne ;Faivre, Alain ;Takahashi, Shinobu ;Daculsi, Guy

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 285 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199702)34:2<165::aid-jbm4>3.0.co;2-o

✦ Synopsis

Previous studies concerning bone drug delivery systems ered from that applied on AP. The results show that 1 g of have provided little data about the amount of drug loaded, AP adsorbed 9.48 mg of hGH. From 0.1 and 0.15 g of hGHone of the essential factors for determining the dose/effect loaded AP, hGH was released in vitro for 2 and 3 weeks, relationship. To investigate this factor, an adsorption method respectively, with a 50% time release (T1/2) at 30 h and involving a therapeutic agent was tested in vitro on an apatitic 72 h, respectively, for the two quantities. The amount of drug calcium phosphate (AP). One milligram of human growth loaded and the determined release kinetics were compatible hormone (hGH) was deposited onto 0.1, 0.15, and 0.2 g of with the action pattern of hGH, indicating that hGH-loaded AP powder over a period of 24 h at 37ЊC. The amount of calcium phosphate supports are suitable for bone-growth hGH loaded was determined by subtracting the dose recov-promotion.