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Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+channels

✍ Scribed by Morten Grunnet; Bo S. Jensen; Søren-Peter Olesen; Dan A. Klaerke


Publisher
Springer
Year
2001
Tongue
English
Weight
81 KB
Volume
441
Category
Article
ISSN
0031-6768

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Solution structure of TsKapa, a charybdo
✍ E. Blanc; C. Lecomte; J. Van Rietschoten; J.M. Sabatier; H. Darbon 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 802 KB

TsKapa (TsK), purified from the Buthidae Tityus serrulatus is a very high potent ligand for small-conductance apaminsensitive calcium-activated potassium channels (SK). It is able to efficiently compete with apamin for binding on this channel (K 0.5 ‫؍‬ 0.3 nM) [Legros, C. et al., FEBS Lett. 390:81-