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AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

✍ Scribed by Eitan Shaulian

Book ID
113528378
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
387 KB
Volume
22
Category
Article
ISSN
0898-6568

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The cyclin kinase inhibitor p16, encoded by the CDKN2A gene, suppresses the transformation of mouse embryonic fibroblasts by oncogenic RAS. In contrast, the c-JUN transcription factor (a major component of AP-1) has been suggested to be required for RAS transformation of rodent fibroblasts. The CDKN