✦ LIBER ✦

Anxiolytic effect of hydroxyzine: a double-blind trial versus placebo and buspirone

✍ Scribed by Malcolm Lader

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 237 KB
Volume: 14
Category: Article
ISSN: 0885-6222
DOI: 10.1002/(sici)1099-1077(199908)14:1+<s94::aid-hup123>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

Benzodiazepines have major drawbacks including lessening of anxiolytic eect in long-term use, impairment of psychological functioning, problems on discontinuation, and addiction potential. Alternatives have been sought including the antihistamines such as hydroxyzine. Two studies are described, one comparing hydroxyzine 50 mg/day with placebo in GAD patients. Signi®cant advantages were found for the active drug. The second GAD evaluation compared hydroxyzine 50 mg/day, buspirone 20 mg/day, and placebo. Hydroxyzine was signi®cantly superior to placebo with buspirone intermediate. Adverse eects were minor and transient. It is concluded that hydroxyzine may prove a useful and safer alternative to the benzodiazepines.

📜 SIMILAR VOLUMES

A double-blind randomized controlled tri

A double-blind randomized controlled trial of ketotifen versus placebo in early diffuse scleroderma

✍ Barry L. Gruber; Lee D. Kaufman 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB 👁 2 views

A double-blind trial of suloctidil v. Pl

A double-blind trial of suloctidil v. Placebo in intermittent claudication

✍ N. A. G. Jones; H. De Haas; J. Zahavi; V. V. Kakkar 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 367 KB 👁 2 views

Effects of doxycycline on progression of

Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial

✍ Kenneth D. Brandt; Steven A. Mazzuca; Barry P. Katz; Kathleen A. Lane; Kenneth A 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 220 KB 👁 2 views

## Abstract ## Objective To confirm preclinical data suggesting that doxycycline can slow the progression of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the medial tibiofemoral compartment. ## Methods In this placebo‐controlled trial, obese women (n = 431)

A double-blind randomized crossover tria

A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome

✍ Dr. Arthur S. Walters; Wayne A. Hening; Neil Kavey; Sudhansu Chokroverty; Steve 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 2 views

A double-blind randomized crossover study of 7.5 mg bromocriptine at bedtime versus placebo was conducted in 30-day phases (with a 2-week washout period between phases) in 6 patients with idiopathic restless legs syndrome. Five patients experienced partial subjective improvement in restlessness and

The effects of intravenous doxycycline t

The effects of intravenous doxycycline therapy for rheumatoid arthritis: A randomized, double-blind, placebo-controlled trial

✍ E. William St.Clair; William E. Wilkinson; David S. Pisetsky; Daniel J. Sexton; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 66 KB 👁 2 views

Steroid-sparing effects of methotrexate

Steroid-sparing effects of methotrexate in systemic lupus erythematosus: A double-blind, randomized, placebo-controlled trial

✍ Fortin, Paul R. ;Abrahamowicz, Michal ;Ferland, Diane ;Lacaille, Diane ;Smith, C 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB 👁 2 views