Antiviral effect of flavonoids on the Dengue virus

✍ Scribed by I. Sánchez; F. Gómez-Garibay; J. Taboada; Dr B. H. Ruiz

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 72 KB
• Volume: 14
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(200003)14:2<89::aid-ptr569>3.0.co;2-c

✦ Synopsis

In the present study we analysed the possible antiviral effect on dengue viruses of different flavonoids extracted and identified at the Chemistry Institute, UNAM, from the Mexican plants Tephrosia madrensis, Tephrosia viridiflora and Tephrosia crassifolia. The flavonoids glabranine and 7-O-methyl-glabranine presented 70% inhibition on the dengue virus at a concentration of 25 mM, while methyl-hildgardtol A, hildgardtol A and elongatine had no effect on viral growth.

Our results show that glabranine and 7-O-methyl-glabranine isolated from Tephrosia s.p. exert a dosedependent inhibitory effect in vitro on the dengue virus.