## Abstract Primary duck hepatocyte (PDH) cultures were established from ducklings congenitally infected with the duck hepatitis B virus (DHBV), plated onto feeder cell layers of irradiated human embryonic lung fibroblasts, and observed for 2 to 3 weeks. This system permitted the survival of the PD
Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model
✍ Scribed by Franck Le Guerhier; Alexandre Thermet; Sylvianne Guerret; Michèle Chevallier; Catherine Jamard; Craig S. Gibbs; Christian Trépo; Lucyna Cova; Fabien Zoulim
- Book ID
- 118564891
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 254 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Primary duck hepatocyte (PDH) cultures, congenitally infected with the duck hepatitis B virus (DHBV), were grown on feeder cell layers of irradiated human embryonic lung fibroblasts and then exposed to a number of compounds with recognized or potential antiviral activity. These compound
Hepatitis B virus (HBV) mutants resistant to treatment with nucleoside or nucleotide analogs and those with the ability to escape from HBV-neutralizing antibody have the potential to infect HBV-vaccinated individuals. To address this potential serious public health challenge, we tested the efficacy