Cisplatin restores p53 function and enha
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Haimei Huang; Shian-Yi Huang; Ting-Ting Chen; Ja-Chi Chen; Chian-Ling Chiou; Ter
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Article
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2004
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John Wiley and Sons
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English
⚖ 350 KB
## Abstract Most HPV‐positive cervical cancer cells possess wild type __p53__ gene, but its normal p53 functions are disrupted by expression of HPVs E6. Treatment with 0–20 μM cisplatin for 24 h in HPV16 E6 containing SiHa cells suppressed E6 mRNA, reduced E6 protein, and restored p53 expression in