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Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers

✍ Scribed by Abdulkarim, Bassam; Sabri, Siham; Deutsch, Eric; Chagraoui, Heddia; Maggiorella, Laurence; Thierry, Jerome; Eschwege, François; Vainchenker, William; Chouaïb, Salem; Bourhis, Jean


Book ID
110066234
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
543 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Most HPV‐positive cervical cancer cells possess wild type __p53__ gene, but its normal p53 functions are disrupted by expression of HPVs E6. Treatment with 0–20 μM cisplatin for 24 h in HPV16 E6 containing SiHa cells suppressed E6 mRNA, reduced E6 protein, and restored p53 expression in