✦ LIBER ✦

Antiviral activity of certain hetarylhydrazones in Mengo virus infected mice

✍ Scribed by Dr. Anneliese Veckenstedt; H. Ulbricht

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 294 KB
Volume: 17
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19770170109

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Out of a series of eleven related hetarylhydrazones four derivatives (ZIMET 124/73, ZIMET 38/74, ZIMET 44/69, and IMET 98/69), after subcutaneous administration (0.5 mmole/kg per injection), were found to possess significant antiviral activity against rapidly progressing and highly lethal Mengo virus encephalitis in mice. After peroral administration (2 mmole/kg per injection) only with IMET 98/69 significant protection was achieved. Drug treatments were given twice daily for 5 days. The effectiveness of compounds was evidenced by significant „rates of protection”︁. Possible relationships between the antiviral activity and the structure of compounds are discussed.

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