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Antitussive effects of two specific κ-opioid agonists, U-50,488H and U-62,066E, in rats

✍ Scribed by Junzo Kamei; Hiroaki Tanihara; Yutaka Kasuya

Book ID
115882916
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
432 KB
Volume
187
Category
Article
ISSN
0014-2999

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Indirect dopamine agonists augment the locomotor activating effects of the κ-opioid receptor agonist U-50,488 in preweanling rats
✍ Sanders A. McDougall; Audrey L. Rodarte-Freeman; Arbi Nazarian 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 1 views

## Opioid receptor agonists (e.g.,488) increase the locomotor activity of preweanling rats, while the same drugs depress the locomotor activity of adults. Curiously, direct stimulation of dopamine (DA) D 2 -like receptors fully attenuates the U-50,488-induced locomotor activity of preweanling rats