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Antitumour activity of an immunoconjugate composed of anti-human astrocytoma monoclonal antibody and neocarzinostatin

โœ Scribed by Kondo, Seiji; Nakatsu, Shouji; Sakahara, Harumi; Kobayashi, Hisataka; Konishi, Junji; Namba, Yuziro


Book ID
123383567
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
720 KB
Volume
29
Category
Article
ISSN
0959-8049

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Wild-type ras has GTPase activity, and this activity is accelerated substantially by GTPase-activating proteins (GAPs). Oncogenic ras species have an abnormally low intrinsic GTPase activity, and this activity is insensitive to GAPs. We confirmed that the anti-ras monoclonal antibody Y13-238 inhibit