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Antitumor liposomes bearing a prodrug of combretastatin A-4 and a tetrasaccharide ligand of selectins

✍ Scribed by N. S. Sitnikov; I. A. Boldyrev; E. V. Moiseeva; A. S. Shavyrin; I. P. Beletskaya; S. Combes; N. V. Bovin; A. Yu. Fedorov; E. L. Vodovozova

Book ID
106521838
Publisher
Springer
Year
2010
Tongue
English
Weight
262 KB
Volume
59
Category
Article
ISSN
1573-9171

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Anti-vascular treatment by targeting proliferating endothelial cells has become a promising option in anti-neoplastic therapy. Combretastatin A-4 prodrug (CA-4PD) has been identified as a selective inhibitor of endothelial cell proliferation, acting by the interruption of microtubule assembly. In th