Antitumor electrochemotherapy: New advances in the clinical protocol

✍ Scribed by Christian Domenge; Stéphane Orlowski; Bernard Luboinski; Thierry De Baere; Guy Schwaab; Jean Belehradek Jr.; Lluis M. Mir

• Book ID: 102649337
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 703 KB
• Volume: 77
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19960301)77:5<956::aid-cncr23>3.0.co;2-1

✦ Synopsis

BACKGROUND.

Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I trial on patients with head and neck squamous cell carcinoma (HNSCC) permeation nodules, we tested variations of ECT protocol to determine how to improve it.

METHODS.

Seven patients with multiple and/or large permeation nodules of HNSCC or of salivary or breast adenocarcinoma were treated in 10 sessions. They received BLM followed by runs of four or eight short (100 p s ) and intense (1000 or 1300 V. cm-I) EP delivered at adjacent positions on the nodules to cover all of the tumor surface.