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Antitumor efficacy of 7α, 17α-dimethyltestosterone in disseminated breast cancer

✍ Scribed by Dr. Theodore J. Cantino; Eugene Eisenberg; Gilbert S. Gordan

Publisher
John Wiley and Sons
Year
1966
Tongue
English
Weight
340 KB
Volume
19
Category
Article
ISSN
0008-543X

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✦ Synopsis

In a study of the antitumor efficacy of androgen derivatives in the treatment of advanced carcinoma of the female breast, a highly potent anabolic and androgenic steroid, 7a,17a-dimethyltestosterone, was compared by the doubleblind technique with 2a-methyldihydrotestosterone. T h e latter is a weak androgen with antitumor efficacy similar to that of testosterone propionate. Both were administered orally, the dimethyllated steroid in a dose of 10 m g daily, the 2a-methyldihydrotestosterone in a dose of 150 mg daily. Five of 25 women treated with 7a,l7a-dimethyltestosterone (20%) h a d objective regressions compared with 2 of 25 women receiving 2a-methyldihydrotestosterone (8%). There was a higher incidence of virilization and BSP retention with 7a,l7a-dimethyltestosterone b u t no jaundice or other evidence of hepatocellular damage.

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