✦ LIBER ✦

Antitumor effects of GANU and other nitrosourea derivatives against transplantable leukemias and solid tumors in mice

✍ Scribed by Gianni Sava; Tullio Giraldi

Publisher: Springer
Year: 1983
Tongue: English
Weight: 293 KB
Volume: 10
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00255754

No coin nor oath required. For personal study only.

✦ Synopsis

The antitumor effects of GANU have been examined in a panel of mouse tumors for which data appear to be lacking in the literature. GANU has significant activity against P388 leukemia and TLX5 lymphoma, and also against the solid tumors B16 melanoma and Lewis lung carcinoma; pulmonary metastases of this tumor are particularly sensitive to the effects of GANU. The effects of GANU on TLX5 lymphoma and Lewis lung carcinoma are less pronounced than those of BCNU and CCNU, as already reported for L1210 leukemia. In contrast with other results obtained with this tumor, chlorozotocin has a less pronounced effect than GANU, and virtually none in lung metastases of Lewis lung carcinoma.

📜 SIMILAR VOLUMES

Antitumor activity of murine tumor necro

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

✍ Katsuyuki Haranaka; Nobuko Satomi; Akiko Sakurai 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 575 KB

Antitumor activity of murine tumor necro

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

✍ Katsuyuki Haranaka; Nobuko Satomi; Akiko Sakurai 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 575 KB

## Abstract The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well e

Potent and broad antitumor effects of DX

Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice

✍ Eiji Kumazawa; Takeshi Jimbo; Yusuke Ochi; Akiko Tohgo 📂 Article 📅 1998 🏛 Springer 🌐 English ⚖ 365 KB

Synthesis and in vivo anticancer and ant

Synthesis and in vivo anticancer and antiangiogenic effects of novel thioxothiazolidin-4-one derivatives against transplantable mouse tumor

✍ S. Chandrappa; H. Chandru; A. C. Sharada; K. Vinaya; C. S. Ananda Kumar; N. R. T 📂 Article 📅 2009 🏛 Springer-Verlag 🌐 English ⚖ 381 KB

Antitumor effect of CPT-11, a new deriva

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

✍ Takashi Tsuruo; Takeshi Matsuzaki; Miyuki Matsushita; Harumi Saito; Teruo Yokoku 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 404 KB

Antitumor effects of interferon in mice

Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously

✍ F. Belardelli; I. Gresser; C. Maury; P. Duvillard; M. Prade; M.-T. Maunoury 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 636 KB

## Abstract Administration of highly purified interferon to DA/2 mice inhibited the growth of interferon‐sensitive or interferon‐resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon