Vinzolidine (VZL), a semisynthetic vinblastine (VLB) derivative, was tested against a variety of solid tumors in the human tumor clonogenic assay (HTCA). The emphasis was on continuous drug exposure because of the schedule-dependency of the vincas and long half-life of VZL. Of tumor types with more
Antitumor and immunological activity of lentinan in comparison with LPS
โ Scribed by Manabu Suzuki; Fumihiko Takatsuki; Yukiko Y. Maeda; Junji Hamuro; Goro Chihara
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 444 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0192-0561
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The in vitro effect of lentinan in inducing activation of killer cells and cytotoxic macrophages has been examined. Human peripheral blood mononuclear cells were cultured with lentinan for 2, 4 and 8 days. After 4 days cytotoxicity was increased 4% by lentinan less than 1,000 ng/ml. After 8 days, it