Antitumor agents XXIII: Helenalin, an antitumor principle from Anaphalis morrisonicola HAY

✍ Scribed by Kuo-Hsiung Lee; Mitsumasa Haruna; Huan-Chang Huang; Bi-Shia Wu; Iris H. Hall

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 241 KB
• Volume: 66
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600660836

✦ Synopsis

A chloroform extract of the whole plant of Anaphalis morrisonicola HAY, showed significant antitumor activity against Ehrlich ascites carcinoma, Walker 256 carcinosarcoma, and P-388 lymphocytic leukemia. Systematic fractionation of the extract led to isolation and characterization of helenalin, a pseudoguaianolide, as the major active principle.