✦ LIBER ✦
Antitumor agents 171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum maxim
✍ Scribed by Toshihiro Fujioka; Yoshiki Kashiwada; Hikaru Okabe; Kunihide Mihashi; Kuo-Hsiung Lee
- Book ID
- 104364668
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 198 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
Cytotoxicities for lobatosides B-E and actinostemmosides B-F, isolated from Actinostemma lobatum, were evaluated against a panel of ca 60 human cancer cell lines. Lobatosides B-E (1-4) were cytotoxic (GIs0 < 1 × 10 -4 M) against all tumor cell lines; 4 showed potent cytotoxicity especially against A-549, SK-MEL-5, and SW-620 cell lines with GIs0 values of 0.14, 0.14, and 0.36 ~tM, respectively.