Antitumor agents. 1771. Design, synthese
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Zheng Ji; Hui-Kang Wang; Kenneth F. Bastow; Xiao-Kang Zhu; Sung Jin Cho; Yung-Ch
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Article
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1997
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Elsevier Science
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English
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Novel water-soluble 4fl-amino-4'-O-demethylepipodophyllotoxin derivatives (6-12), designed to enhance minor groove binding ability, were synthesized and screened against NCI's in vitro disease-oriented human tumor cells. Among them, 4'-O-demethyl-4fl-[N-(l'"-methyl-4'"-nitro-pyrrole-2'"-carbonyl)-4"