Antitumor activity of three mouse mammary cancer cell lines after interferon-gamma gene transfection

Transfection of the genes for interleuki

Transfection of the genes for interleukin-12 into the K1735 melanoma and the EMT6 mammary sarcoma murine cell lines reveals distinct mechanisms of antitumor activity

✍ James P. Moran; Scott A. Gerber; Celeste A. Martin; John G. Frelinger; Edith M. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 347 KB

## Abstract Interleukin 12 (IL‐12) is a pleiotropic cytokine with multiple effects on the immune system. The antitumor effects of locally produced IL‐12 were examined in 2 tumor model systems. IL‐12 expressing EMT6 mammary sarcomas (EMT6/IL‐12) grew temporarily and then regressed resulting in mice