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Antitumor activity of living or killedBrucella: Modification of the non-specific cytotoxic effector cells

✍ Scribed by L. Dazord; Y. le Garrec; I. Florentin

Publisher: Springer-Verlag
Year: 1983
Tongue: English
Weight: 509 KB
Volume: 15
Category: Article
ISSN: 0340-7004
DOI: 10.1007/bf00199464

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✦ Synopsis

At various times after injection of living or killed smooth (S) or rough (R) BrucelIa abortus mice received a graft of the semi-aUogenic EL 4 lymphoma and their survival was studied. In parallel, the NK activity of spleen and peritoneal cells, the level of serum interferon (IFN), and the cytotoxic activity of peritoneal macrophages were investigated. Protection against the lymphoma lasted longer after injection of R organisms than after S. The parallelism between the in vivo resistance to E L 4 lymphoma and the augmentation of NK and macrophage activity was satisfactory with R but not with S. IFN production did not seem to be correlated with R antitumor activity. The antitumor effect of Brucella cannot therefore be simply explained on the basis of modification of the non-specific cytotoxie effector mechanisms.

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