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Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2′-deoxyuridine derivative

✍ Scribed by Setsuo Takeda; Jun-ichi Yamashita; Hitoshi Saito; Junji Uchida; Hiroyasu Satake; Yuji Yamada; Norio Unemi; Yusuke Wataya; Hikoya Hayatsu


Publisher
Springer
Year
1991
Tongue
English
Weight
586 KB
Volume
29
Category
Article
ISSN
0344-5704

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Drug release was controlled by a combination of prodrug and polymer matrix. Prodrugs of 5-fluoro-2'-deoxyuridine with different physicochemical properties were synthesized by esterification with aliphatic acids (propionate, n-butyrate, and n-pentanoate). Microspheres containing these ester prodrugs