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Antitumor activity of delocalized lipophilic cation, MKT-077 in human carcinomas obtained from fresh surgical specimens

โœ Scribed by Yohei Chiba; T. Kubota; Masahiko Watanabe; Yoshihide Otani; Tatsuo Teramoto; Yoichi Matsumoto; Keizo Koya; Masaki Kitajima

Book ID
106285471
Publisher
Springer
Year
1999
Tongue
English
Weight
73 KB
Volume
4
Category
Article
ISSN
1341-9625

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๐Ÿ“œ SIMILAR VOLUMES

Selective antitumor activity of MKT-077,
Selective antitumor activity of MKT-077, a delocalized lipophilic cation, on normal cells and cancer cells in vitro
โœ Chiba, Yohei; Kubota, Tetsuro; Watanabe, Masahiko; Otani, Yoshihide; Teramoto, T ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 125 KB ๐Ÿ‘ 2 views

Background and Objectives: 1-Ethyl-2-{[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)]-4-oxothiazolidin-2-ylidenemethyl}pyridium chloride (MKT-077, formerly known as FJ776), a delocalized lipophilic cation, is known to accumulate in the mitochondria, according to the negative potential inside the mitoc