Antitubercular activity of substituted 5-oxo-1-thiocarbamoyl-3-pyrazoline-4-alkanoic acid derivatives

✍ Scribed by Arthur A. Santilli; Dong H. Kim; Francis J. Gregory

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 197 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640646

✦ Synopsis

Several novel pyrazolin-5-ones prepared by the cyclization of variously substituted thiosemicarbazone derivatives of ethyl formylsuccinate, ethyl acetylsuccinate, and ethyl acetylglutarate were tested for antitubercular activity against Mycobacterium tuberculosis, human type, strain H37Rv, by a tube dilution technique. Minimum inhibitory concentrations (MIC) for these derivatives ranged from 0.05 to 100 Mg/ml. The most active compound was ethyl 3-methyl-l-methylthiocarbamoyl-5-oxo-3-pyrazoline-4acetate (MIC = 0.05-0.1 Mg/ml).

Keyphrases 5-Oxo-l-thiocarbamoyI-3-pyrazoline-4-alkanoic acid derivatives-synthesis, antitubercular activity Pyrazolin-5-one derivatives-synthesis, antitubercular activity Antitubercular activity-synthesis and screening of substituted 5-0x0-1- thiocarbamoyl-3-pyrazoline-4-alkanoic acid derivatives