Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum

✍ Scribed by Yunjiang Feng; Rohan A. Davis; Melissa L. Sykes; Vicky M. Avery; Anthony R. Carroll; David Camp; Ronald J. Quinn

• Book ID: 104097578
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 193 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.161

✦ Synopsis

Bioassay-guided fractionation of the crude CH 2 Cl 2 /MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC 50 values of 0.077, 0.032, and 1.33 lM against Trypanosoma brucei brucei, respectively.