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Antithrombotic Effect of SM-20302, a Nonpeptide GPIIb/IIIa Antagonist, in a Photochemically Induced Thrombosis Model in Guinea Pigs

✍ Scribed by Seiya Horisawa; Munekiyo Kaneko; Yoshiharu Ikeda; Yasuyuki Ueki; Teruo Sakurama

Book ID: 117259011
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 134 KB
Volume: 94
Category: Article
ISSN: 0049-3848
DOI: 10.1016/s0049-3848(98)00215-1

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We examined the antithrombotic effect of KBT-3022, a novel antiplatelet agent, on photochemically induced arterial thrombosis in the guinea-pig saphenous artery, and compared its effect with that of aspirin and that of ticlopidine. Pretreatment with KBT-3022 [0.1 mg (0.2 µmole), 0.3 mg (0.7 µmole),