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Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats

โœ Scribed by Yasunori Gonda; Shigeto Hirata; Ken-ichi Saitoh; Yoshikazu Aoki; Mitsunobu Mohri; Komakazu Gomi; Taisuke Sugihara; Takao Kiyota; Shuji Yamamoto; Torao Ishida; Ikuro Maruyama


Book ID
116086390
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
709 KB
Volume
71
Category
Article
ISSN
0049-3848

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Adult respiratory distress syndrome (ARDS) and disseminated intravascular coagulation (DIC) are serious complications of sepsis. Thrombomodulin, an important endothelial anticoagulant, binds thrombin to generate activated protein C (APC). To determine whether thrombomodulin purified from human urine