Antithrombogenic effect of a graphite, benzalkonium chloride, and heparin coating on a flexible polyvinyl chloride plastic implant in the rabbit
✍ Scribed by Farb, Richard B. ;Kaplan, Harold M.
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 309 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
In vzvo and in vitro experiments described herein have demonstrated that the (:BH coating is antithrombogenic when placed on PVC, as tested in the blood system of rabbits for periods up to 2 weeks. In vitro clotting times cannot be correlated with the in vivo thrombogenicity of the same implants. For example, dog and man have very similar in vitro clotting times, but very dissimilar in vivo prosthetic thrombosis problems. In vCo and in vitro tests are for the most part not comparable in that they do not measure the same things. However, both in vivo and in vitro tests proved the GBH-treated vinyl to be antithrombogenic. It may be concluded from the available data that a flexible plastic can be treated with GBH and become antithrombogenic for a practicable period of time.