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Antithetical effect of tumor necrosis factor-αgene polymorphism on coal workers' pneumoconiosis (CWP)

✍ Scribed by Xin-Tao Wang; Yoshinori Ohtsuka; Kiyonobu Kimura; Miho Muroi; Takashi Ishida; Junpei Saito; Mitsuru Munakata


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
97 KB
Volume
48
Category
Article
ISSN
0271-3586

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Tumor necrosis factor-␣ (TNF) is recognized as a central mediator of mineral dust-induced lung fibrosis, and genetic polymorphisms of the TNF promoter have been reported to influence levels of TNF production. To assess whether polymorphisms within the TNF promoter gene are associated with susceptibi