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Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product

โœ Scribed by W.Roy Smythe; Imran Mohuiddin; Mustafa Ozveran; Xiaobo X. Cao


Book ID
114490499
Publisher
CTSNet
Year
2002
Tongue
English
Weight
791 KB
Volume
123
Category
Article
ISSN
1097-685X

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Bcl-xL antisense oligonucleotide and cis
โœ James E. Littlejohn; Xiaobo Cao; Steven D. Miller; Mustafa K. Ozvaran; Daniel Ju ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 702 KB

## Abstract Bclโ€xL functions as a dominant regulator of apoptotic cell death and is implicated in chemotherapeutic resistance of malignant pleural mesothelioma (MPM). Mesothelioma cell lines demonstrate increasing levels of Bclโ€xL as resistant clones are selected __invitro__. Moreover, upon introdu