✦ LIBER ✦

Antisense therapy for lymphomas

✍ Scribed by Finbarr E. Cotter

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 58 KB
Volume: 15
Category: Article
ISSN: 0278-0232
DOI: 10.1002/(sici)1099-1069(199702)15:1<3::aid-hon583>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

  antisense; BCL-2; apoptosis; lymphoma 'gene silencing', by synthetic oligonucleotides, as a therapeutic tool. In the field of lymphomas obvious targets include follicular lymphoma with the t(14;18) translocation, deregulated expression of the BCL-2 gene, chemoresistance and subsequent protection against lymphoma cell death.

Binding of a sequence-specific oligonucleotide to a targeted length of mRNA should occur with a high level of specificity. The resultant formation of the mRNA-DNA duplex would, if the relevant portion of mRNA has been targeted, suppress the translation of the targeted message into protein. If the production of that protein, such as BCL-2, is essential for the survival of the

📜 SIMILAR VOLUMES

Combined therapy for cutaneous t-cell ly

Combined therapy for cutaneous t-cell lymphomas

✍ Lourdes Z. Niscel; Bijan Safai; Rosa Ong; Sanford Kempin; Hipolito-Rosillo Pouss 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 179 KB

Radiation therapy for intraocular lympho

Radiation therapy for intraocular lymphoma

✍ J.Lillian Chou; Duane E. Myers; Mary E. Young; James D. Easley 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 113 KB

Monoclonal antibody therapy for lymphoma

✍ Peter Campbell; Robert Marcus 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 139 KB

Monoclonal antibodies are an exciting advance in the treatment of lymphoma. They are safe and well-tolerated, and exhibit little cross-resistance with conventional chemotherapeutic agents. In indolent lymphomas, antibody therapy has shown useful response rates, both as first-line therapy and in rela

Corticosteroid therapy for lymphomas and

Corticosteroid therapy for lymphomas and chronic lymphocytic leukemia

✍ Dr. Ediz Z. Ezdinli; Leon Stutzman; C. William Aungst; Dincer Firat 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 837 KB

Radiation therapy for primary orbital ly

Radiation therapy for primary orbital lymphoma

✍ Cliff K.S. Chao; Hsiu-san Lin; V. Rao Devineni; Morton Smith 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 467 KB

Antisense MBD2 gene therapy inhibits tum

Antisense MBD2 gene therapy inhibits tumorigenesis

✍ Andrew Slack; Veronica Bovenzi; Pascal Bigey; M. A. Ivanov; Shyam Ramchandani; S 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

## Abstract ## Background Aberration in the pattern of DNA methylation is one of the hallmarks of cancer. We present data suggesting that dysregulation of MBD2, a recently characterized member of a novel family of methylated DNA binding proteins, is involved in tumorigenesis. Two functions were as