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Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice

✍ Scribed by Yin Liang; Melville C. Osborne; Brett P. Monia; Sanjay Bhanot; Lynnetta M. Watts; Pengxiang She; Stephanie O. DeCarlo; Xiaoli Chen; Keith Demarest

Book ID: 119325145
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 181 KB
Volume: 54
Category: Article
ISSN: 1532-8600
DOI: 10.1016/j.metabol.2005.01.030

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## Abstract TRB3 (a mammalian homolog of __Drosophila__) is emerging as an important player in the regulation of insulin signaling. TRB3 can directly bind to Ser/Thr protein kinase Akt, the major downstream kinase of insulin signaling. Conversely, physical exercise has been linked to improved gluco