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Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-β in Fibrotic Renal Disease in the Rat in Vivo

✍ Scribed by Christoph Daniel; Yoshitugu Takabatake; Masayuki Mizui; Yoshitaka Isaka; Hiroshi Kawashi; Harald Rupprecht; Enyu Imai; Christian Hugo

Book ID
117021676
Publisher
American Society for Investigative Pathology
Year
2003
Tongue
English
Weight
555 KB
Volume
163
Category
Article
ISSN
0002-9440

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## Abstract ## Background/aims Transforming growth factor β (TGFβ1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFβ1 in a cell‐free system and activated hepatic stellate cells (HSCs), and anti