A series of N-heterocyclic and N-heterocyclic alkyl derivatives of bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid was synthesized as potential antiradiation and anticancer agents. The compounds were prepared by the reactions of the heterocyclic halides with bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid. A dithio acid derivative, 3,3-dimercapto-2cyanoacryloylpyrrolidide, was also prepared. Several compounds, including the dithio acid derivative, provided good radiation protection to mice. None of the compounds screened showed appreciable anticancer activities in two leukemia systems.
Keyphrases Antiradiation compounds, potential-series of Nheterocyclic aminoethyl disulfiides and aminoethanethiosulfuric acids synthesized and screened Nitrogen heterocycles-series of Nheterocyclic aminoethyl disulfides synthesized and screened for antiradiation activity Disulfides, N-heterocyclic aminoethyl-series synthesized and screened for antiradiation activity Thiosulfuric acids, aminoethane-series synthesized and screened for antiradiation activity 0 Radioprotective agents, potential-series of N-heterocyclic aminoethyl disulfides and aminoethanethiosulfuric acids synthesized and screened * Antitumor tests, using two leukemia systems, were carried out for some of these compounds by the Division of Cancer Treatment, National Cancer Institute, in accordance with their protocol (9).