๐”– Bobbio Scriptorium
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Antipyretic effects of indomethacin in liver metastases of solid tumors

โœ Scribed by Allen B. Bredt; George J. D. Girey

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
391 KB
Volume
50
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Six cases of fever in patients with dominant hepatic metastases from a variety of solid tumors are presented. The elevated temperature in each case was due to the malignant process itself without evidence of infection. After failure to control fever with various antipyretics and antibiotics, indomethacin promptly controlled fever in all six patients. Prior reports of antipyresis from indomethacin in hematologic malignancies and solid tumors are reviewed. Both the mechanism of fever due to the malignant process itself and the possible mechanism of indomethacin's antipyretic effect are presented. The major thrust of this report is the clinical usefulness of indomethacin for the management of liver metastases with uncontrollable fever.

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