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Antipruritic effect of flavonol and 1,4-naphthoquinone derivatives from Impatiens balsamina L.

✍ Scribed by Kyoko Ishiguro; Hisae Oku

Book ID: 101287476
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 192 KB
Volume: 11
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199708)11:5<343::aid-ptr103>3.0.co;2-4

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✦ Synopsis

To investigate the effect of antipruritic agents, we developed an animal model to allow quantitative estimation of itching. Dextran T40 and compound 48/80, agents which cause histamine release, significantly induced scratching behaviour in mice. A 35% ethanol extract (IB) of white petals of Impatiens balsamina L. significantly inhibited the scratching behaviour in this model. Kaempferol, quercetin and 1,4-naphthoquinone derivatives in IB were demonstrated to show antipruritic effects.

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