Antiprotease capacity in acute pancreatitis

✍ Scribed by Mr A. J. Goodman; N. C. Bird; A. G. Johnson

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 278 KB
• Volume: 73
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800731012

✦ Synopsis

Abstract
Serial measurements of circulating antiproteases were carried out on 42 consecutive patients admitted with acute pancreatitis. In the 7 days following admission the serum levels of α1 antitrypsin (α1 AT), α1 antichymotrypsin (α1 ACT) and the trypsin inhibitory capacity (TIC) increased by more than 300 per cent. The serum concentration of α2 macroglobulin (α2M) alone showed a decline which was most profound in those patients with severe acute pancreatitis. Initial experience of fresh frozen plasma as a source of extrinsic antiproteases in severe acute pancreatitis is that it fails to prevent the decline in α2M or increase the already elevated TIC of the patients' serum.