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Antiproliferative response of human leukemic cells. Modulation of cytosolic protein kinase C activity by phytohemagglutinin

โœ Scribed by Borrebaeck, Carl A.K.; Bristulf, Jesper; Jergil, Bengt

Book ID
122949145
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
520 KB
Volume
38
Category
Article
ISSN
0304-3835

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## Abstract The increase of intracellular free calcium concentration ([Ca^2+^]~i~) and protein kinase C (PKC) activity are two major early mitogenic signals to initiate proliferation of human T cells. However, a rapid change in intracellular pH (pH~i~), acidification or alkalinization during the ac