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Antiproliferative effects of PCA-4230, a new antithrombotic drug, in vascular smooth muscle cells

✍ Scribed by Marcela Del Rio; Carlos Sunkel; Fernando Larcher; M. Pilar Ortega

Book ID
110002831
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
359 KB
Volume
120
Category
Article
ISSN
0007-1188

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## Abstract Prostacyclin (PGI~2~) has been shown to inhibit proliferation in vascular smooth muscle cells. To clarify the underlying molecular mechanism, we investigated the vasoprotection of beraprost (a PGI~2~ agonist) both in vivo and in vitro. Beraprost eliminated increases in proliferation of