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Antiproliferative effects of heparin on normal and transformed NIH/3T3 fibroblasts.

✍ Scribed by Simone Cavari; Marco Ruggiero; Simonetta Vannucchi

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 306 KB
Volume: 17
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1993.1140

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We studied the effect of heparin on proliferation and signalling in normal NIH/3T3 fibroblasts, and in cells transformed by different oncogenes. Heparin inhibited the proliferation of normal as well as of v‐sis and v‐erbB transformed fibroblasts in the presence of serum, but failed to inhibit v‐erbB‐driven proliferation in serum‐starved cultures; under these conditions, heparin inhibited by approximately 50% the proliferation of normal and v‐sis‐ transformed cells. Heparin also inhibited PDGF‐induced cell proliferation and inositol lipid turnover in v‐sis transformants, but it did not affect PDGF mitogenic signalling in NIH/3T3 fibroblasts.

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