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Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase

✍ Scribed by X. Li; G. Wang; J. Zhao; H. Ding; C. Cunningham; F. Chen; D. C. Flynn; E. Reed; Q. Q. Li

Publisher
Springer
Year
2005
Tongue
English
Weight
263 KB
Volume
62
Category
Article
ISSN
1420-682X

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## Abstract Lithium, a therapeutic agent for bipolar disorder, can induce G2/M arrest in various cells, but the mechanism is unclear. In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC‐7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr‐15). T