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Antiproliferative activity of doxorubicin and aminoanthraquinone derivatives on chinese hamster ovary cells

✍ Scribed by Edwin M. Uyeki; Akira Nishio; Philip J. Wittek; C. C. Cheng

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
419 KB
Volume
70
Category
Article
ISSN
0022-3549

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✦ Synopsis

A study of the antiproliferative activity of doxorubicin and several substituted aminoanthraquinone derivatives on Chinese hamster ovary cells was conducted. Doxorubicin and a derivative each inhibited cell proliferation at low concentrations, the latter being more potent than doxorubicin. A structure-activity relationship of these compounds is discussed in connection with an earlier postulated N-O-O triangulation hypothesis.

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