Antiplatelet aggregation principles from Glycosmis citrifolia

✍ Scribed by Yann-Lii Leu; Yu-Yi Chan; Tian-Shung Wu; Che-Ming Teng; Kuo-Tung Chen

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 94 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(1998)12:1+<s77::aid-ptr256>3.0.co;2-j

✦ Synopsis

Twelve acridone alkaloids, citracridone-I (1), atalaphyllidine (2), noracronycine (3), des-N-methylnoracronycine (4), 5-hydroxynor-acronycine (5), des-N-methylacronycine (6), N-methyl severifoline (7), 5-hydroxy-N-methyl severifoline (8), glycocitrine-II (9), 3-O-methyl-glycocitrine-II (10), glycocitrine-I (11) and pyranofoline (12); one 2-quinolone alkaloid, 4,8-dimethoxy-1-methyl-3(3-methylbut-2-enyl)2-quinolone (13) were isolated and characterized from the stem and root barks of Glycosmis citrifolia. Their structures were determined by spectral analyses. On bioactive evaluation, compounds 1 and 2 almost completely inhibited platelet aggregation induced by arachidonic acid (100 mM), collagen (10 mg/mL) and PAF (2 ng/mL). Compounds 2, 4 and 13 also showed an inhibitory effect on AA and collagen-induced rabbit platelet aggregation. In the structure and activity relationship of acridone alkaloids, the acridone nucleus bearing a pyranyl moiety is a most important factor for the antiplatelet aggregation activity.