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Antiplasmodial structure–activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives

✍ Scribed by Adoración Marin; Lidia Moreira Lima; Beatriz Solano; Esther Vicente; Silvia Pérez Silanes; Séverine Maurel; Michel Sauvain; Ignacio Aldana; Antonio Monge; Eric Deharo


Book ID
113617469
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
157 KB
Volume
118
Category
Article
ISSN
0014-4894

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1,4-Di-N-oxide quinoxaline-2-carboxamide
✍ Elsa Moreno; Silvia Pérez-Silanes; Shravani Gouravaram; Abinav Macharam; Saioa A 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 429 KB

To gain insight into the mechanism of action, the redox properties of 37 quinoxaline-2-carboxamide 1,4-di-N-oxides with varying degrees of anti-tuberculosis activity were studied in dimethylformamide (DMF) using cyclic voltammetry and first derivative cyclic voltammetry. For all compounds studied, e