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Antiparkinsonian drug doses and neuroleptic receptors

โœ Scribed by M. Titeler; P. Seeman


Book ID
112655080
Publisher
Springer
Year
1978
Tongue
English
Weight
304 KB
Volume
34
Category
Article
ISSN
1420-682X

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Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent d