Antiparasitic properties of homoallylamines and related compounds

✍ Scribed by Alicia Gómez-Barrio; David Montero-Pereira; Juan J. Nogal-Ruiz; José A. Escario; Susana Muelas-Serrano; Vladimir V. Kouznetsov; Leonor Y. Vargas Méndez; Juan M. Urbina Gonzáles; Carmen Ochoa

• Book ID: 111490499
• Publisher: Versita
• Year: 2006
• Tongue: English
• Weight: 383 KB
• Volume: 51
• Category: Article
• ISSN: 1230-2821
• DOI: 10.2478/s11686-006-0010-z

✦ Synopsis

Abstract

A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.